0704-883-0675     |      dataprojectng@gmail.com

PHARMACOGNOSTIC AND ANTIDIARRHOEA ACTIVITY OF LEAVES OF BAUHINIA RUFESCENS LAM (CAESALPINIOIDEAE)

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 5000

ABSTRACT

Bauhinia rufescens Lam (Caesalpinioidae) is a scandent shrub or small tree measuring between 1-3m high but sometimes up to 8m high, often scraggy, stunted and multistemmed. The leaves are stomachic, anti-diarrheotic and anti-dysentric. This study is on the pharmacognostic, phytochemical, antimicrobial and anti-diarrhoea (using castor oil induced dirrhoea method), studies of B. rufescens. The microscopic studies revealed the presence of anomocytic both at the upper and lower layer, trichomes, calcium oxalate, petiole of 0.57mm, lamina of average length 7mm and width 9.8mm. Quantitative evaluation of the crude plant drug revealed the following parameters, Alcohol soluble extractive of 30.1%, Percentage moisture content: 11%, Total ash value 0.66%, Water insoluble ash value of 6%, Alcohol soluble extractive value of 5.6%. Chemo-microscopy revealed presence of Cellulose, Lignin, Starch, Tannins, Proteins, Mucilage and Calcium oxalate. Preliminary phytochemical studies of the methanolic extract revealed the presence of carbohydrates, saponins, tannins, alkaloids, cardiac glycoside and flavonoid. The methanolic extract was found to be effective against castor oil induced diarrhea on the experimental rats at doses of; 50mg/kg (statistically significant (P<0.1) after one hour), 100mg/kg (statistical significance after one hour (P<0.05) and after two hours (P<0.02)), 200mg/kg (statistical significance after one hour (P<0.05) and after two hours (P<0.02)). For the antimicrobial screening, The minimum inhibitory concentration (MIC) of Staphylococcus aureus, Streptococcus feacalis, Escherichia coli, Pseudomonas aeruginosa and Candida krusei were each 2.5mg/ml respectively while that for Corynebacterium ulcereans, Corynebacterium hemolyticum, Shigella dysenteriae and Candida albicans were found to be each 5mg/ml respectively. For the minimum bactericidal concentration (MBC), Corynebacterium hemolyticum, Shigella vii dysenteriae, and the fungus Candida albicans showed the highest MBC of 20mg/ml each, followed by Corynebacterium ulcereans, Escherichia coli, and the fungus Candida krusei with MBC of each 10mg/ml while Staphylococcus aureus, Streptococcus feacalis and Pseudomonas aeruginosa, showed the least MBC of 5mg/ml. The study revealed that the leaves of Bauhinia rufescens contain secondary metabolites that are responsible for its anti-diarrhoeal and antimicrobial activity and thus support the use of this plant by medicinal practitioners in diarrhoeal treatment.




FIND OTHER RELATED TOPICS


Related Project Materials

MITIGATING THE EFFECT OF TOPOLOGY IN CELLULAR MOBILE NETWORK USING MATLAB

BACKGROUND OF THE STUDY

Wireless Ad hoc Networks are networks in which wireless nodes cooperate to establish network connectivity and per...

Read more
The impact of mobile marketing on customer retention: A case study of Airtel Nigeria in Niger State

Background of the Study
Mobile marketing has emerged as a powerful tool for businesses to engage with customers and foster...

Read more
IMPACT OF QUALITY ASSURANCE ACTIVITIES ON THE MANAGEMENT OF SECONDARY SCHOOLS IN KADUNA STATE, NIGERIA

ABSTRACT

This study investigated the “Impact of Quality Assurance Activities on the Management of Secondary Schools in Kaduna State...

Read more
THE EFFECT OF TRADE AND FINANCE ON ECONOMIC GROWTH AND DEVELOPMENT IN NIGERIA

ABSTRACT

Several statistical approaches were implemented to carry out this research, inwhich Central Bank of Nigeria (CBN), Nigeria Insti...

Read more
PUMP CAPACITY DETERMINATION FOR TWO-PHASE VERTICAL FLUID FLOW

Statement Of The Problem

It is important to accurately predict the pressure drop accross a production system. This has b...

Read more
An Investigation of Succession Planning and Business Continuity: A Study of Family-Owned Enterprises in Kano State

Background of the Study

Succession planning is critical for ensuring business continui...

Read more
A Study of Financial Statement Fraud Detection in the Nigerian Banking Sector: A Case of UBA Plc in Kano State

Background of the Study

Financial statement fraud is a serious issue in the banking sector, as it involves the intentional manipulation o...

Read more
A Study on the Role of Branding in Attracting Customers to Small Businesses: A Case Study of Fashion Designers in Adamawa State

Background of the Study

Branding has become a crucial element in differentiating businesses and attracting customers in...

Read more
The Impact of Decentralization on Local Economic Development in Sokoto North LGA, Sokoto State: A Case Study of Market Reforms

Background of the Study

Decentralization refers to the transfer of political, administrative, and financial authority fr...

Read more
INFLUENCE OF PARENTING STYLE ON CHILDREN IN UGBOWO COMMUNITY

BACKGROUND OF THE STUDY

Parenting style is a psychological construct representing standard strategies that parents use i...

Read more
Share this page with your friends




whatsapp